Endurance Training with Moderate and Intense Intensity Along with the Consumption of Safflower Extract Improved the Oxidative Damage of Testicular Tissue Caused by Dexamethasone in Adult Male Rats

Background: Chronic use of dexamethasone, especially in athletes, is associated with reproductive disorders. Objectives: This study aimed to investigate the effect high and moderate intensity endurance training along consumption safflower extract on testicular oxidative damage testosterone level male rats treated dexamethasone. Methods: A total 45 Wistar were divided into controlled groups. Dexamethasone was subcutaneously injected for five days at a dose 8 mg/kg. High exercises performed ten weeks (five week) speeds 28 34 m/min, respectively, treadmill. The seed (500 mg/kg body weight) administered daily during period by gavage. At end given period, tissue sampling measure malondialdehyde, antioxidant capacity, Nrf2, levels. Results: results showed that (P = 0.000) as well exercise alone 0.04) caused significant increase Nrf2 expression animals receiving dexamethasone compared group. No change observed group control However, detected its some groups exercise, intense extract. Conclusions: It concluded training, extract, had potential prevent infertility